Jeremy M. Baskin

Associate Professor

Publications

Please see a complete publication list on the Baskin Lab website.

Selected publications from the Baskin Lab:

Bumpus TW, Huang S, Tei R, and Baskin JM. “Click chemistry–enabled CRISPR screening reveals GSK3 as a regulator of PLD signaling.” Proc Natl Acad Sci USA (2021) 118, 48, e2025265118.
Tei R*, Morstein J*, Shemet A, Trauner D^†, and Baskin JM^†. “Optical control of phosphatidic acid signaling.” ACS Cent Sci (2021) 7, 7, 1205–1215. *Equal contribution; ^†Co-corresponding authors.
Liang D, Cheloha R, Watanabe T, Gardella TJ, and Baskin JM. “Activity-based, bioorthogonal imaging of phospholipase D reveals spatiotemporal dynamics of GPCR-Gq signaling.” Cell Chem Biol (2021) 28, 1–7.
Shami Shah A, Cao X, White AC, Baskin JM. “PLEKHA4 Promotes Wnt/β-catenin Signaling-Mediated G1/S Transition and Proliferation in Melanoma.” Cancer Res (2021) 81, 2029–43.
Tei R and Baskin JM. “Spatiotemporal Control of Phosphatidic Acid Signaling with Optogenetic, Engineered Phospholipase Ds.” J Cell Biol (2020) 219, 3, e201907013.
Liang D, Wu K*, Tei R*, Bumpus TW, Ye J, and Baskin JM. “A real-time, click chemistry imaging approach reveals stimulus-specific subcellular locations of phospholipase D activity.” Proc Natl Acad Sci USA (2019) 116, 31, 15453–62. *Equal contribution.
Shami Shah A, Batrouni AG, Kim D, Punyala A, Cao W, Han ML, Smolka MB, and Baskin JM. “PLEKHA4/kramer attenuates Dishevelled ubiquitination to modulate Wnt and planar cell polarity signaling.” Cell Rep (2019) 27, 2157–70.
Bumpus TW and Baskin JM. “Clickable Substrate Mimics Enable Imaging of Phospholipase D Activity.” ACS Cent Sci (2017) 3, 10, 1070-1077.
Bumpus TW and Baskin JM. “A Chemoenzymatic Strategy for Imaging Cellular Phosphatidic Acid Synthesis.” Angew Chem Int Ed (2016) 55, 13155-13158.

G60 ST Olin
jeremy.baskin@cornell.edu
607/255-2887

Education

Postdoc, Yale University
PhD, University of California, Berkeley
BS, Massachusetts Institute of Technology

Departments and programs

Chemistry and Chemical Biology

Keywords

Biochemistry, Cell Biology, Chemical Biology, Imaging Probes, Lipids and Membranes

Barbara A. Baird

Horace White Professor

Publications

[ A complete list of publications can be found on the Baird-Holowka Group webpage]

Bag, Nirmalya, D. Holowka, B. Baird. 2019. Imaging FCS Delineates Subtle Heterogeneity in Plasma Membranes of Resting Mast Cells. bioRciv
Ramezani, M., M.M. Wilkes, T. Das, D. Holowka, D. Eliezer and B. Baird. 2019. Regulation of exocytosis and mitochondrial relocalization by Alpha-synuclein in a mammalian cell model. npj Parkinson’s Disease 5(1): 1-17
Mitra, E.D., S.C. Whitehead, D. Holowka, B. Baird and J.P. Sethna. 2018. Computation of a Theoretical Membrane Phase Diagram and the Role of Phase in Lipid-Raft-Mediated Protein Organization. J. Phys. Chem. B 122(13): 3500-3513
Wakefield, D.L., D. Holowka and B. Baird. 2017. The FceRI signaling cascade and integrin trafficking converge at patterned ligand surfaces. Mol. Biol. Cell 28(23): 3383-3396
Korzeniowski, M.K., E. Wisniewski, B. Baird, D.A. Holowka and T. Balla. 2017. Molecular anatomy of the early events in STIM1 activation - oligomerization or conformational change? J. Cell Sci. 130(17): 2821-2832
Holowka, D. and B. Baird. 2017. Mechanisms of epidermal growth factor receptor signaling as characterized by patterned ligand activation and mutational analysis. Biochimica et Biophysica Acta – Biomembranes 1859: 1430-1435
Shelby, S.A., S.L. Veatch, D.A. Holowka and B.A. Baird. 2016. Functional nanoscale coupling of Lyn kinase with IgE-FcεRI is restricted by the actin cytoskeleton in early antigen-stimulated signaling. Mol. Biol. Cell 27(22): 3645-3658
Sun, C., D.L. Wakefield, Y. Han, D.A. Muller, D.A. Holowka, B.A. Baird and W.R. Dichtel. 2016. Graphene Oxide Nanosheets Stimulate Ruffling and Shedding of Mammalian Cell Plasma Membranes. Chem 1(2): 273-286
Wilson, J.D., S.A. Shelby, D. Holowka and B. Baird. 2016. Rab11 Regulates the Mast Cell Exocytic Response. Traffic 17(9): 1027-1041
Holowka, D. and B. Baird. 2016 Roles for lipid heterogeneity in immunoreceptor signaling Biochimica et Biophysica Acta 1861(8): 830-836
Singhai, A., D.L. Wakefield, K.L. Bryant, S.R. Hammes, D. Holowka and B. Baird. 2015. Spatially Defined EGF Receptor Activation Reveals an F-Actin-Dependent Phospho-Erk Signaling Complex. Biophys. J. 107(11): 2639-2651.
Holowka, D. and B. Baird. 2015. Nanodomains in Early and Later Phases of FcεRI Signaling. Essays in Biochemistry: Membrane Nanodomains; Vol. 57, pp. 147-163.
Kelly, C.V., D.L. Wakefield, D.A. Holowka, H.G. Craighead and B.A. Baird. 2014. Near-Field Fluorescence Cross-Correlation Spectroscopy on Planar Membrane. ACS Nano 8(7): 7392-7404.
Wilkes, M.M., J.D. Wilson, B. Baird and D. Holowka. 2014. Activation of Cdc42 is Necessary for Sustained Oscillations of Ca²⁺ and PIP2 Stimulated by Antigen in RBL Mast Cells. Biology Open 3(8): 700-710.
Chylek, L.A., D.A. Holowka, B.A. Baird and W.S. Hlavacek. 2014. An interaction library for the FcεRI signaling network. Front. Immunol. 5: 172.
Welch, M. Elizabeth, N.L. Ritzert, H. Chen, N.L. Smith, M.E. Tague, Y. Xu, B.A. Baird, H.D. Abruña and C.K. Ober. 2014. Generalized Platform for Antibody Detection using the Antibody Catalyzed Water Oxidation Pathway. J. Am. Chem. Soc. 136(5): 1879-1883.
Shelby, S.A., D. Holowka, B. Baird and S.L. Veatch. 2013. Distinct Stages of Stimulated FcεRI Receptor Clustering and Immobilization Are Identified through Superresolution Imaging. Biophys. J. 105(10): 2343-2354.
Bryant, K.L., M.A. Antonyak, R.A. Cerione, B. Baird and D. Holowka. 2013. Mutations in the Polybasic Juxtamembrane Sequence of Both Plasma Membrane- and Endoplasmic Reticulum-localized Epidermal Growth Factor Receptors Confer Ligand-independent Cell Transformation. J. Biol. Chem. 288(48): 34930-34942.
Veatch, S.L., B.B. Machta, S.A. Shelby, E.N. Chiang, D.A. Holowka and B.A. Baird. 2012. Correlation Functions Quantify Super-resolution Images and Estimate Apparent Clustering Due to Over-counting. PLoS One 7(2): e31457.
Veatch, S., E. Chiang, P. Sengupta, D. Holowka and B. Baird. 2012. Quantitative Nano-Scale Analysis of IgE-FcεRI Clustering and Coupling to Early Signaling Proteins. J. Phys. Chem. B. 116(23): 6923-6935.

660A ST Olin
bab13@cornell.edu
607/255-4095

Education

Damon Runyon Postdoctoral Fellow, National Cancer Institute, NIH
PhD, Cornell University
BS, Knox College

Departments and programs

Chemistry and Chemical Biology

Keywords

Biophysical studies of membrane receptor proteins, signal transduction and cellular responses

Jeremy M. Baskin

Associate Professor

Publications

Education

Departments and programs

Links

Keywords

Barbara A. Baird

Horace White Professor

Publications

Education

Departments and programs

Links

Keywords