The Department of Molecular Biology and Genetics engages in cutting-edge research, training and teaching to solve basic questions in the life sciences and to apply biological knowledge to critical medical, agricultural and environmental problems. Our goal is to inspire the next generation of scientists, teachers and communicators by providing research mentorship and classroom instruction in biochemistry, bioinformatics, cell biology, genetics and molecular biology and by initiating and participating in collaborative research across the Cornell campuses.

The explosion of genome-scale data over the last decade offers unprecedented opportunities to understand fundamental principles of biology and to apply biological knowledge to critical medical, agricultural and environmental problems. Every day, faculty in the Department of Molecular Biology and Genetics (MBG) engage in cutting-edge research, training and teaching to advance scientific discovery and answer basic questions in the life sciences. MBG faculty and students continuously deliver the highest standard of research because of their demonstrated excellence in linking genomes to gene and protein function in the context of cells, tissues, organisms, and the environment.

Our goal is to inspire and train the next generation of scientists, teachers and communicators by providing research mentorship and classroom instruction in biochemistry, bioinformatics, cell biology, genetics, molecular biology and related disciplines and by initiating and participating in collaborative research across the Cornell campuses.

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Jeffrey Warren Roberts

Robert J. Appel Professor Emeritus of Molecular Biology and Genetics,

Publications

  • B.Z. Ring, W.S. Yarnell, and J.W. Roberts (1996). Function of E. coli RNA Polymerase Sigma Factor s70 in Promoter-Proximal Pausing. Cell, 86, 485-493.
  • C.W. Roberts and J.W. Roberts (1996). Base Specific Recognition of the Nontemplate Strand of Promoter DNA by E. coli RNA Polymerase. Cell 86, 495-501 (1996)
  • M.T. Marr and J.W. Roberts (1997). "Promoter Recognition As Measured by Binding of Polymerase to Nontemplate Strand Oligonucleotide." Science, 276, 1258-1260.
  • Ko, D.C., Marr, M.T., Guo, J., and Roberts, J.W. (1998). A Surface of E. coli s70 Required for Promoter Function and Antitermination by Phage Lambda Q Protein. Genes and Development 12, 3276-3285.
  • Roberts, J.W., Yarnell, W., Bartlett, E., Guo, J., Marr, M., Ko, D., Sun, H., and Roberts, C.W. (1999). Antitermination by Phage l Q Protein. Cold Spring Harbor Symposium on Quantitative Biology 63, 319-325.
  • Yarnell, W.S., and Roberts, J.W. (1999). Mechanism of Intrinsic Transcription Termination and Antitermination. Science 284, 611-615.
  • Marr, M.T., & J.W. Roberts (2000).  "Function of Transcription Factors GreA and GreB at a Regulatory Pause Site", Molecular Cell, 6, 1275-1285.
  • Marr, M.T., Saul A. Datwyler, Claude F. Meares, & Jeffrey W. Roberts (2001).  "Restructuring of an RNA polymerase holoenzyme elongation complex by lambdoid phage Q proteins"  Proc. Nat. Acad. Sci. USA, 98, 8972-8978
  • Park, J.-S., M.T. Marr, & J.W. Roberts (2002).  "E. coli Transcription Repair Coupling Factor (Mfd protein) Rescues Arrested Complexes by Promoting Forward Translocation"  Cell  109, 757-767
  • Nickels, B.E., Roberts, C.W., Sun, H., Roberts, J.W., & Hochschild, A.  (2002).  "The s70 subunit of RNA polymerase is contacted by the lQ antiterminator during early elongation "  Molecular Cell,  10, 611-622
  • Adelman, K., La Porta, A., Santangelo, T.J., Lis, J.T., Roberts, J.W., & Wang, M.D. (2002)  "Single Molecule Analysis of RNA Polymerase Elongation Reveals Uniform Kinetic Behavior"  Proc. Nat. Acad. Sci. USA 99, 13538-13543
  • Santangelo, T.J., Mooney, R.A., Landick, R., & Roberts, J.W., (2003).  "RNA Polymerase mutations that impair conversion to a termination resistant complex by Q antiterminator proteins"  Genes & Development, 17, 1281-1292
  • Ryder, Andrew M. & Jeffrey W. Roberts (2003).  “Role of the Non-template Strand of the Elongation Bubble in Intrinsic Transcription Termination”.  J. Mol. Biol. 334, 205-213
  • Guo, Jingshu and Roberts, Jeffrey W. (2004).  “DNA Binding Regions of Q Proteins of Phages land f80”  J. Bacteriology 186, 3599-3608
  • Santangelo, T.J. and Roberts, J.W., (2004).  “Forward Translocation Is the Natural Pathway of RNA Release at an Intrinsic Terminator”.  Mol. Cell 14, 117-126.
  • Park, J.-S. & J.W. Roberts (2006).  “Role of DNA Bubble Rewinding in Enzymatic Transcription Termination”  Proc. Nat. Acad. Sci. USA 103, 4870-4875
  • Nickels, B.E., Roberts, C.W., Roberts, J.W., and Hochschild, A. (2006).  “RNA-Mediated Destabilization of the s70 Region 4/b Flap Interaction Facilitates Engagement of RNA Polymerase by the Q Antiterminator”  Mol. Cell. 24, 457-468
  • Roberts, J.W. (2006).  “RNA Polymerase, A Scrunching Machine” Science 314, 1097-1098.  [A Perspective]

Jeffrey A. Pleiss

Associate Professor

Helen Nivison

Liberty Hyde Bailey Professor

Linda K. Nicholson

Professor

Yuxin Mao

Professor

Jun Liu

Professor

John Lis

Barbara McClintock Professor of Molecular Biology & Genetics

Ruth E. Ley

Professor

Siu Sylvia Lee

Professor

Hojoong Kwak

Assistant Professor

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