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Jeremy M. Baskin
My research interests center on pioneering innovative chemical approaches to probe the cell biology of diverse classes of lipids, with a major focus on developing new molecular imaging methods.
Lipids are a diverse group of metabolites that function as energy stores, components of membranes, and signaling molecules, and dysregulation of lipid metabolism occurs in many diseases. While lipids have been traditionally studied using in vitro or genetic techniques, chemical biology approaches can enable the rapid and precise interrogation of lipid biology within living systems. The Baskin Laboratory deploys a unique blend of chemical biology, biochemistry, and cell biology approaches to develop innovative methods for imaging and probing various classes of lipids in vivo. Collectively, our studies elucidate mechanisms of fundamental biological processes and also contribute to the understanding of diseases caused by perturbations in lipid metabolism, with a focus on multiple sclerosis and other diseases of the myelin sheath.
Biochemistry, Cell Biology, Chemical Biology, Imaging Probes, Lipids and Membranes
- Chemistry and Chemical Biology
- Chemistry and Chemical Biology
- Biochemistry, Molecular and Cell Biology
- Weill Institute for Cell and Molecular Biology
Baskin Lab Publications at Cornell:
- Bumpus TW and Baskin JM. “Greasing the wheels of lipid biology with chemical tools.” Trends Biochem Sci (2018), DOI: 10.1016/j.tibs.2018.09.011.
- Bumpus TW, Liang FJ, and Baskin JM. “Ex Uno Plura: Differential labeling of phospholipid biosynthetic pathways with a single bioorthogonal alcohol.” Biochemistry (2018) 57, 2, 226-230.
- Bumpus TW and Baskin JM. “Clickable Substrate Mimics Enable Imaging of Phospholipase D Activity.” ACS Cent Sci (2017) 3, 10, 1070-1077.
- Knopf KM, Murphy BL, MacMillan SN, Baskin JM, Barr MP, Boros E, and Wilson JJ. “In Vitro Anticancer Activity and in Vivo Biodistribution of Rhenium(I) Tricarbonyl Aqua Complexes.” J Am Chem Soc (2017) 139, 40, 14302-14314.
- Bumpus TW and Baskin JM. “A Chemoenzymatic Strategy for Imaging Cellular Phosphatidic Acid Synthesis.” Angew Chem Int Ed (2016) 55, 13155-13158.
Selected Publications, Reviews, and Patents from Graduate & Postdoctoral Work:
- *Baskin JM, *Wu X, Christiano R, Oh M, Schauder CM, Gazzerro E, Messa M, Baldassari S, Assereto S, Biancheri R, Zara F, Minetti C, Raimondi A, Simons M, Walther TC, Reinisch KM, De Camilli P. “The leukodystrophy protein FAM126A/Hyccin regulates PI4P synthesis at the plasma membrane.” Nat Cell Biol, 18, 132–38 (2016).
- Nakatsu F*, Baskin, JM*, Chung J, Tanner LB, Shui G, Lee SY, Pirruccello M, Hao M, Ingolia NT, Wenk MR, De Camilli P. (2012) “PtdIns4P synthesis by PI4KIIIα at the plasma membrane and its impact on plasma membrane identity.” J Cell Biol, 199, 1003–16 (2012).
- Baskin JM*, Dehnert KW*, Laughlin ST*, Amacher SL, Bertozzi CR. (2010) “Visualizing enveloping layer glycans during zebrafish early embryogenesis.” Proc Natl Acad Sci USA, 107, 10360–65 (2010).
- Laughlin ST*, Baskin JM*, Amacher SL, Bertozzi CR. “In vivo imaging of membrane-associated glycans in developing zebrafish.” Science, 320, 664–67 (2008).
- Codelli JA, Baskin JM, Agard NJ, Bertozzi CR. “Second-generation difluorinated cyclooctynes for copper-free click chemistry.” J Am Chem Soc, 130, 11486–93 (2008).
- Baskin JM, Prescher JA, Laughlin ST, Agard NJ, Chang PV, Miller IA, Lo A, Codelli JA, Bertozzi CR. “Copper-free click chemistry for dynamic in vivo imaging.” Proc Natl Acad Sci USA, 104, 16793–97 (2007).
- Agard NJ*, Baskin JM*, Prescher JA, Lo A, Bertozzi CR. “A comparative study of bioorthogonal reactions with azides.” ACS Chem Biol, 1, 644–48 (2006).
- Baskin JM and Bertozzi CR. “Copper-free click chemistry: Bioorthogonal reagents for tagging azides.” Aldrichimica Acta, 43, 15–23 (2010).
- Baskin JM and Bertozzi CR. “Bioorthogonal click chemistry: Covalent labeling in living systems.” QSAR Comb Sci, 26, 1211–19 (2007).
- Baskin JM and Bertozzi CR. “Copper-free click chemistry.” In Click Chemistry for Biotechnology and Materials Science. Ed. J. Lahann. pp. 25–51, Wiley (2009).
- Bertozzi CR, Agard NJ, Prescher JA, Baskin JM, Sletten EM. “Compositions and methods for modification of biomolecules.” US Patent Nos. 7,807,619 (Oct 5, 2010), 8,461,298 (Apr 30, 2013), and 8,461,298 (Jun 11, 2013).