Brett P. Fors
Professor
Education
- Elings Postdoctoral Fellow, University of California, Santa Barbara
- PhD, Massachusetts Institute of Technology
- BSc, Montana State University
David B. Collum
Betty R. Miller Professor
Publications
- Ketone Enolization with Sodium Hexamethyldisilazide: Solvent- and Substrate-Dependent E–Z Selectivity and Affiliated Mechanisms. Woltornist, R.A. and Collum, D.B., J. Am. Chem. Soc. 2021, 143, 17452-17464.
- Reactions of Sodium Diisopropylamide: Liquid-Phase and Solid–Liquid Phase-Transfer Catalysis by N,N,N′,N″,N″-Pentamethyldiethylenetriamine. Ma, Y.; Woltornist, R.A.; Algera, R. F.; Collum, D.B., J. Am. Chem. Soc. 2021, 143, 13370-13381.
- Structure, Reactivity, and Synthetic Applications of Sodium Diisopropylamide. Woltornist, R.A.; Ma, Y.; Algera, R.F.; Zhou, Y; Zhang, Z; Collum, D.B., Synthesis 2020, 52, 1478-1497.
- Pseudoephedrine-Derived Myers Enolates: Structures and Influence of Lithium Chloride on Reactivity and Mechanism. Zhou, Y.; Jermaks, J.; Keresztes, I.; MacMillan, S. N.; Collum, D. B. J. Am. Chem. Soc. 2019, 141, 5444-5460.
- Structures and Reactivities of Sodiated Evans Enolates: Role of Solvation and Mixed Aggregation on the Stereochemistry and Mechanism of Alkylations. Zhang, Z.; Collum, D. B. J. Am. Chem. Soc. 2019, 141, 388.
- Disodium Salts of Pseudoephedrine-Derived Myers Enolates:Stereoselectivity and Mechanism of Alkylation. Zhou, Y.; Keresztes, I.; MacMillan, S. N.; Collum, D. B. J. Am. Chem. Soc. 2019, 141, 16865.
- Lithium Amino Alkoxide−Evans Enolate Mixed Aggregates: Aldol Addition with Matched and Mismatched Stereocontrol. Jermaks, J.; Tallmadge, E. H.; Keresztes, I.; Collum, D. B. J. Am. Chem. Soc. 2018, 140, 3077 — 3090.
- Lithium Diisopropylamide: Non-Equilibrium Kinetics and Lessons Learned about Rate Limitation. Algera, R. F.; Gupta, L.; Hoepker, A. C.; Liang, J.; Ma, Y.; Singh, K. J.; Collum, D. B. J. Org. Chem. 2017, 82, 4513.
- Lithium Hexamethyldisilazide-Mediated Enolization of Highly Substituted Aryl Ketones: Structural and Mechanistic Basis of the E/Z Selectivities. Mack, K. A.; McClory, A.; Zhang, H.; Gosselin, F.; Collum, D. B. J. Am. Chem. Soc. 2017, 139, 12182.
- Structure–Reactivity Relationships in Lithiated Evans Enolates: Influence of Aggregation and Solvation on the Stereochemistry and Mechanism of Aldol Additions. Tallmadge, E. H.; Jermaks, J.; Collum, D. B J. Am. Chem. Soc. 2016, 138, 345.
Education
- PhD, Columbia University
- MS, Columbia University
- MA, Columbia University
- BS, Cornell University
Departments and programs
Links
Keywords
Physical organic chemistry, organolithium chemistry, organosodium chemistry, kinetics and reaction mechanism
Geoffrey W. Coates
Tisch University Professor
Publications
• Ye, R.; Sun, X.; Mao, X.; Alfonso, F. S.; Baral, S.; Liu, C.; Coates, G. W.; Chen, P. “Optical sequencing of single synthetic polymers” Nature Chemistry, 2024, 16, 210–217.
• Zhou, Z.; LaPointe, A. M.; Coates, G. W. Atactic, Isotactic, and Syndiotactic Methylated Polyhydroxybutyrates: An Unexpected Series of Isomorphic Polymers” J. Am. Chem. Soc. 2023, 145, 25983–25988.
• Lu, Y.; Coates, G. W. “Pairing-Enhanced Regioselectivity: Synthesis of Alternating Poly(lactic-co-glycolic acid) from Racemic Methyl-Glycolide” J. Am. Chem. Soc. 2023, 145, 22425–22432.
• Zhou, Z.; LaPointe, A. M.; Shaffer, T. D.; Coates, G. W. “Nature-inspired methylated polyhydroxybutyrates from C1 and C4 feedstocks” Nature Chemistry, 2023, 15, 856–861.
• Parke, S. M.; Lopez, J. C.; Cui, S.; LaPointe, A. M.; Coates, G. W. “Polyethylene Incorporating Diels-Alder Comonomers: A “Trojan Horse” Strategy for Chemically Recyclable Polyolefins” Angew. Chem. Int. Ed. 2023, 62, e202301927.
• Hester, H. G.; Abel, B. A.; Coates, G. W. “Ultra-High Molecular Weight Poly(Dioxolane): Enhancing the Mechanical Performance of a Chemically Recyclable Polymer” J. Am. Chem. Soc. 2023, 145, 8800–8804.
• Arroyave, A.; Cui, S.; Lopez, J. C.; Kocen, A. L.; LaPointe, A. M.; Delferro, M.; Coates, G. W. “Catalytic Chemical Recycling of Post-Consumer Polyethylene” J. Am. Chem. Soc. 2022, 144, 23280–23285.
• Kocen, A. L.; Cui, S.; Lin, T.-W.; LaPointe, A. M.; Coates, G. W. “Chemically Recyclable Ester-Linked Polypropylene” J. Am. Chem. Soc. 2022, 144, 12613–12618.
• Popowski, Y.; Lu, Y.; Coates, G. W.; Tolman, W. B. “Stereocomplexation of Stereoregular Aliphatic Polyesters: Change from Amorphous to Semicrystalline Polymers with Single Stereocenter Inversion” J. Am. Chem. Soc. 2022, 144, 8362–8370.
• Abel, B. A.; Snyder, R. L.; Coates, G. W. “Chemically recyclable thermoplastics from reversible-deactivation polymerization of cyclic acetals” Science, 2021 373, 783–789.
• Lu, Y.; Swisher, J. H.; Meyer, T. Y.; Coates, G. W. “Chirality-Directed Regioselectivity: An Approach for the Synthesis of Alternating Poly(Lactic-co-Glycolic Acid)” J. Am. Chem. Soc. 2021, 143, 4119–4124.
• You, W.; Ganley, J. M.; Ernst, B. G.; Peltier, C. R.; Ko, H.-Y.; DiStasio, Jr.; R. A.; Knowles, R. R.; Coates, G. W. “Expeditious synthesis of aromatic-free piperidinium-functionalized polyethylene as alkaline anion exchange membranes” Chem. Sci., 2021, 12, 3898–3910.
• Lidston, C. A. L.; Abel, B. A.; Coates, G. W. “Bifunctional Catalysis Prevents Inhibition in Reversible-Deactivation Ring-Opening Copolymerizations of Epoxides and Cyclic Anhydrides” J. Am. Chem. Soc. 2020, 142, 20161–20169.
• Lamb, J. R.; Hubbell, A. K.; MacMillan, S. N.; Coates, G. W. “Carbonylative, Catalytic Deoxygenation of 2,3-Disubstituted Epoxides with Inversion of Stereochemistry: An Alternative Alkene Isomerization Method” J. Am. Chem. Soc. 2020, 142, 8029–8035.
• Lipinski, B. M.; Morris, L. S.; Silberstein, M. N.; Coates, G. W. “Isotactic Poly(Propylene Oxide): A Photodegradable Polymer with Strain Hardening Properties” J. Am. Chem. Soc. 2020, 142, 6800–6806.
• Sifri, R. J.; Padilla-Vélez, O.; Coates, G. W.; Fors, B. P. “Controlling the Shape of Molecular Weight Distributions in Coordination Polymerization and Its Impact on Physical Properties” J. Am. Chem. Soc. 2020, 142, 1443–1448.
• Abel, B. A.; Lidston, C. A. L.; Coates, G. W. “Mechanism-Inspired Design of Bifunctional Catalysts for the Alternating Ring-Opening Copolymerization of Epoxides and Cyclic Anhydrides” J. Am. Chem. Soc. 2019, 141, 12760–12769.
• Hubbell, A. K.; LaPointe, A. M.; Lamb, J. R.; Coates, G. W. “Regioselective Carbonylation of 2,2-Disubstituted Epoxides: An Alternative Route to Ketone-Based Aldol Products” J. Am. Chem. Soc. 2019, 141, 2474–2480.
• You, W.; Padgett, E.; MacMillan, S. N.; Muller, D. A.; Coates, G. W. “Highly Conductive and Chemically Stable Alkaline Anion Exchange Membranes via ROMP of trans-Cyclooctene Derivatives” Proc. Nat. Acad. Sci. 2019, 116, 9729–9734.
• Eagan, J. E.; Xu, J.; Di Girolamo, R.; Thurber, C. M.; Macosko, C. W.; LaPointe, A. M.; Bates, F. S.; Coates, G. W. “Combining Polyethylene and Polypropylene: Enhanced Performance with PE/iPP Multiblock Polymers” Science 2017, 355, 814−816.
Education
- Postdoc, California Institute of Technology
- Ph.D., Stanford University
- B.A., Wabash College
Departments and programs
Links
Keywords
Polymer synthesis, stereoselective catalysis, mechanism of metal catalyzed reactions
Jeremy M. Baskin
Associate Professor
Publications
Please see a complete publication list on the Baskin Lab website.
Selected publications from the Baskin Lab:
- Bumpus TW, Huang S, Tei R, and Baskin JM. “Click chemistry–enabled CRISPR screening reveals GSK3 as a regulator of PLD signaling.” Proc Natl Acad Sci USA (2021) 118, 48, e2025265118.
- Tei R*, Morstein J*, Shemet A, Trauner D†, and Baskin JM†. “Optical control of phosphatidic acid signaling.” ACS Cent Sci (2021) 7, 7, 1205–1215. *Equal contribution; †Co-corresponding authors.
- Liang D, Cheloha R, Watanabe T, Gardella TJ, and Baskin JM. “Activity-based, bioorthogonal imaging of phospholipase D reveals spatiotemporal dynamics of GPCR-Gq signaling.” Cell Chem Biol (2021) 28, 1–7.
- Shami Shah A, Cao X, White AC, Baskin JM. “PLEKHA4 Promotes Wnt/β-catenin Signaling-Mediated G1/S Transition and Proliferation in Melanoma.” Cancer Res (2021) 81, 2029–43.
- Tei R and Baskin JM. “Spatiotemporal Control of Phosphatidic Acid Signaling with Optogenetic, Engineered Phospholipase Ds.” J Cell Biol (2020) 219, 3, e201907013.
- Liang D, Wu K*, Tei R*, Bumpus TW, Ye J, and Baskin JM. “A real-time, click chemistry imaging approach reveals stimulus-specific subcellular locations of phospholipase D activity.” Proc Natl Acad Sci USA (2019) 116, 31, 15453–62. *Equal contribution.
- Shami Shah A, Batrouni AG, Kim D, Punyala A, Cao W, Han ML, Smolka MB, and Baskin JM. “PLEKHA4/kramer attenuates Dishevelled ubiquitination to modulate Wnt and planar cell polarity signaling.” Cell Rep (2019) 27, 2157–70.
- Bumpus TW and Baskin JM. “Clickable Substrate Mimics Enable Imaging of Phospholipase D Activity.” ACS Cent Sci (2017) 3, 10, 1070-1077.
- Bumpus TW and Baskin JM. “A Chemoenzymatic Strategy for Imaging Cellular Phosphatidic Acid Synthesis.” Angew Chem Int Ed (2016) 55, 13155-13158.
Education
- Postdoc, Yale University
- PhD, University of California, Berkeley
- BS, Massachusetts Institute of Technology
Departments and programs
Links
Keywords
Biochemistry, Cell Biology, Chemical Biology, Imaging Probes, Lipids and Membranes